The Mississippi River near Hannibal, Missouri, USA

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Check prices for these dates

Next weekend
Jun 26 - Jun 28
In two weeks
Jul 3 - Jul 5

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Our top choices for East Prairie hotels

Premier Room, 1 Bedroom, Non Smoking

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (774 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is CA $69
CA $74 total
includes taxes & fees
Jun 28 - Jun 29
New Orleans Inn Portageville
Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,001 reviews)
The price is CA $157
CA $181 total
includes taxes & fees
Jul 9 - Jul 10
Drury Inn & Suites Sikeston, MO
Exterior

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (416 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."
United States
Soheila
The price is CA $106
CA $118 total
includes taxes & fees
Jun 22 - Jun 23
The Riverstone Hotel Charleston-Sikeston
Individually decorated, individually furnished, desk, blackout drapes

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (791 reviews)
"I love it there."
United States
Sharika West
The price is CA $94
CA $107 total
includes taxes & fees
Jun 22 - Jun 23
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Room, 1 Queen Bed, Non Smoking

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (64 reviews)
"Great hotel for the price!!! Remodel very nice and modern. "
United States
Amy
The price is CA $117
CA $134 total
includes taxes & fees
Jun 22 - Jun 23
Super 8 By Wyndham Marston
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (571 reviews)
"Ok place to say the night if you are looking for a place to sleep. "
United States
Paul
The price is CA $75
CA $89 total
includes taxes & fees
Jul 6 - Jul 7
Country Hearth Inn & Suites Union City
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (93 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is CA $156
CA $176 total
includes taxes & fees
Jul 9 - Jul 10
Fairfield Inn & Suites by Marriott Sikeston
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (525 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is CA $90
CA $107 total
includes taxes & fees
Jul 12 - Jul 13
Quality Inn Union City US 51
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (399 reviews)
"The room was clean, the breakfast was good. We enjoyed our stay."
United States
David
The price is CA $123
CA $147 total
includes taxes & fees
Jul 15 - Jul 16
Sleep Inn at Discovery Park of America
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,000 reviews)
"When I stay at hotels I like to find hotels like this one for the $$$ value . This hotel was clean and the bed was very comfortable. Room 237 . I didn’t hear any interstate noise . I didn’t eat the breakfast but the coffee was very good . I would stay here again ."
United States
Kurt
The price is CA $96
CA $110 total
includes taxes & fees
Jul 20 - Jul 21
Days Inn and Suites by Wyndham Sikeston
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,001 reviews)
"Very convenient and staff was great."
United States
jeanne
The price is CA $118
CA $134 total
includes taxes & fees
Jul 19 - Jul 20
Best Western Plus Sikeston I-55
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (186 reviews)
"Friendly staff, comfortable bed."
United States
James
The price is CA $168
CA $200 total
includes taxes & fees
Jul 6 - Jul 7
Hampton Inn Union City
Standard Room, 2 Double Beds, Non Smoking

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (499 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
The price is CA $90
CA $104 total
includes taxes & fees
Jun 22 - Jun 23
Reelfoot Lake Inn
Iron/ironing board, free WiFi, bed sheets

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (139 reviews)
"Enjoyed our stay. All the appliances worked and our air conditioner kept us cool! Will definitely stay here again!"
United States
Sheryl
The price is CA $76
CA $90 total
includes taxes & fees
Jun 23 - Jun 24
Country Yard Inn and Suite
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (393 reviews)
"Traveling through the area. It met our needs."
United States
Pamela
The price is CA $81
CA $96 total
includes taxes & fees
Jun 29 - Jun 30
Hospitality House Union City I 69 / US 51
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (641 reviews)
"Clean rooms,"
United States
Karl
The price is CA $84
CA $93 total
includes taxes & fees
Jul 12 - Jul 13
Super 8 by Wyndham Charleston/Sikeston East MO
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"Room was very nice and in very clean condition and hotel staff was very helpful and polite. The breakfast was very delicious and coffee served all day. The hotel smelled very nice and had a very welcoming feeling. Will definitely book with them again"
United States
Joseph
The price is CA $180
CA $204 total
includes taxes & fees
Jul 2 - Jul 3
TownePlace Suites by Marriott Sikeston
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (289 reviews)
"The web site said smoking rooms, this is untrue. I was fine with that, but my room smelled like a smoking room. There where cobwebs on the lamps and the tables where dirty. The shower was dirty and had a whole in the ceiling. The outside was very dirty. I would never stay at this hotel aging. I would tell everyone to stay far away from it as they can."
United States
Cyndy
The price is CA $97
CA $108 total
includes taxes & fees
Jul 10 - Jul 11
Quality Inn Cairo I-57
Free WiFi, bed sheets

Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
2.5 star property
Marston
6.0 out of 10, (124 reviews)
"The room was great, TV was awesome. Staff was friendly."
United States
Stanley
The price is CA $64
CA $80 total
includes taxes & fees
Jun 28 - Jun 29
Travel Inn Marston I-55 by Hotel O
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Reelfoot Lake Inn

Reelfoot Lake Inn

10/10 Excellent
"Clean"
paul 3-night trip
Posted 17 hours ago
Reelfoot Lake Inn

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
The price is CA $89 per night from Jul 19 to Jul 20
CA $89
CA $102 total
Jul 19 - Jul 20
includes taxes & fees
7/10 Good! (651 reviews)

Hotels in East Prairie with star rating

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
Members always get our best prices. Find our best East Prairie hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from CA $74 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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